Thioflavin T CAS: 2390-54-7 | MF: C17H19ClN2S | MW: 318.86, Buy Histological Stains & Dyes for Histology, Cytology, Microbiology, Hematology & Biology Lab from TriStains at Chemical World.
Thioflavin T (CAS No. 2390-54-7) is a fluorescent chemical derived from benzothiazoles that are generally used in life science research laboratories to detect amyloid fibrils. When this dye is bound to amyloid structures, it will experience a spectral shift to form intense fluorescence, which is observable under the application of UV or blue light excitation. This characteristic allows it to be an important reagent in the detection of amyloid deposits in tissue samples and in cultured cells. Despite the structural similarity with Thioflavin S, which is related to the presence of a methyl thio group, Thioflavin T is different in terms of its solubility properties and usage. It is widely applied in the fields of fluorescence microscopy, spectrofluorometric experiments and amyloid aggregation experiments in biochemical and molecular research laboratories.
Applications
- Cytology and Histology: Identification and observation of intracellular and extracellular protein aggregates in tissue sections.
- Microbiology: Detection of amyloid components of bacterial biofilms and microbial systems.
- Hematology: Staining of blood smears and bone marrow proteinaceous deposits.
- Protein Aggregation Research: The kinetics of amyloid fibrillation and aggregation mechanisms in vitro.
Key features
- High and selective binding to amyloid fibrils.
- Increased fluorescence emission interaction.
- Suitable for quantitative spectrofluorometric analysis.
- Fit with standardized staining and analysis protocols.
General Description
Thioflavin T (CAS No. 2390-54-7) is designed to bind beta-sheet-rich protein, resulting in strong fluorescence that can be easily visualized and quantified. It has found use in neuroscience studies, protein misfolding studies, pathology studies, and in-depth biochemical studies. The identification of amyloid fibrils and protein aggregates in both research and clinical samples requires a well-performing fluorescent staining reagent.
Want to buy Thioflavin T? Chemical World is a supplier of laboratory-tested Thioflavin T, which is subject to quality control to ensure quality research performance. The product comes in different pack sizes that have all the technical documentation to facilitate laboratory operations. Discover new prices, packaging, or technical information are available to the researchers and procurement departments on the platform. A special sales team provides support to the bulk supply and institutional purchase inquiries. Thioflavin T (CAS: 2390-54-7 Molecular Formula: C17H19ClN2S Molecular Weight: 318.86) is a convenient fluorescent dye and research chemical used to detect amyloid and other applications in life science.
About Brand
TriStains provides a marketplace for histology and biological stains, which is comprehensive enough to encompass the peculiar requirements of laboratories specializing in Histology, Cytology, Microbiology, and Hematology. With a reputation for exceeding quality expectations, TriStains performance is outstanding, which allows for the resolution of cell and tissue components fundamental to life sciences to be clearly visualized. Each product under the TriStains series is validated for accuracy, reliability, and consistency. TriStains, which manufactures and markets stains and indicators in various packaging, offers laboratories turnkey solutions for all their staining and indicator needs, improving accuracy in every experiment.
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| Alternate Names | Basic Yellow 1 |
| Application | Thioflavin T is a cell-permeable dye capable of binding amyloid fibrils |
| CAS Number | 2390-54-7 |
| Molecular Weight | 318.86 |
| Molecular Formula: | C17H19ClN2S |
Thioflavin T is a cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Thioflavin T is useful in monitoring stacked sheet aggregates.
| Physical State | Solid |
| Solubility | Soluble in water (5 mg/ml), alcohol (100 mg/ml), methanol (0.1% w/v), and glacial acetic acid:water (1:1) (50 mg/ml). |
| Storage | Store at room temperature |
| Melting Point | >100° C |
| Fluoresence | ex ~385 nm-free (~437 nm), em ~445 nm-free (~485 nm); ex 350 nm, em 438 nm; ex 450 nm, em 482 nm |
SAFETY INFORMATION
| WGK Germany | 3 |
| PubChem CID | 16953 |
| MDL Number | MFCD00011944 |
| EC Number | 219-228-9 |
| Beilstein Registry | 3922452 |
| SMILES | CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-] |
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