Quercetin dihydrate CAS: 6151-25-3 | MF: C15H10O7 · 2H2O | MW: 338.27, Part Number S10161, Buy Histological Stains & Dyes for Histology, Cytology, Microbiology, Hematology & Biology Lab from TriStains at Chemical World.
Quercetin dihydrate is a naturally occurring flavonoid compound that is derived from various plant sources. It is commonly found in fruits, vegetables, and grains, and it is known for its antioxidant and anti-inflammatory properties at Dawnscientific.com.
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| Alternate Names | 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate, 3,3,4,5,7-Pentahydroxyflavone dihydrate |
| Application | Quercetin Dihydrate is a natural flavonoid antiproliferative kinase inhibitor |
| CAS Number | 6151-25-3 |
| Molecular Weight | 338.27 |
| Molecular Formula | C15H10O7 · 2H2O |
| Supplemental Information | This is classified as a Dangerous Good for transport and may be subject to additional shipping charges |
Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and interrupting the role of this enzyme in propagating cellular responses to growth factors. Quercetin is further described to inhibit nucleotide-dependent kinase enzymes through competition with ATP and GTP, demonstrating inhibition of pp60src phosphotransferase, tyrosine protein kinase, calcium- and phospholipid-dependent protein kinase, and cyclic GMP phosphodiesterases. Inhibition of PI 4-kinase (1-phosphatidylinositol 4-kinase) and PI-4-phosphate 5-kinase (1-phosphatidylinositol 4-phosphate 5-kinase) by Quercetin blocks the participation of these enzymes in signal transduction pathways and reduces cellular levels of the second messenger IP3 (inositol 1,4,5-trisphosphate), decreasing the release of intracellular Ca2+ stores. The antiproliferative and cytotoxic effects of Quercetin on cultured breast cancer cells are attributed to inhibition of PI 4-kinase and PI-4-phosphate 5-kinase, reduction of IP3 levels, and blockade of oncogenic growth signaling. Quercetin was shown to induce apoptosis in tumor cell lines at the G1 and S phases. Potential fatty acid synthase, PKC, and ATP5 (mitochondrial ATPase) inhibitor as well as an SIRT1 activator. SIRT1 deacetylates histones. Quercetin Dihydrate is an inhibitor of Pim-1 and an activator of GPR30.
| Physical State | Solid |
| Solubility | Soluble in DMSO (68 mg/ml at 25° C), Acetic Acid (1 mg/ml), Aqueous Alkali (1 mg/ml), water (<1 at 25° C), and ethanol (21 mg/ml at 25° C). |
| Storage | Store at room temperature |
| Melting Point | 310-315° C |
| Refractive Index | n20D 1.82 (Predicted) |
| IC50 | Monoamine oxidase A: IC50 = 10 nM (bovine); CYP19: IC50 = 12 nM (human); Aldose Reductase: IC50 = 14.8 nM (human); Pim-1: IC50 = 43 nM (human); CYP1B1: IC50 = 77 nM (human) |
| Ki Data | D4DR: Ki= 7.8 nM (human); Enoyl-acyl-carrier protein reductase: Ki= 22 nM (plasmodium falciparum); CYP1B1: Ki= 23 nM (human); 5'-nucleotidase: Ki= 45.3 nM (rat); CYP1A1: Ki= 660 nM (human) |
SAFETY INFORMATION
| WGK Germany | 3 |
| RTECS | LK8950000 |
| PubChem CID | 5284452 |
| Merck Index | 14: 8034 |
| MDL Number | MFCD00149487 |
| EC Number | 204-187-1 |
| Beilstein Registry | 317313 |
| SMILES | C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O.O.O |
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