Evans Blue C.I. 23860 CAS: 314-13-6 | MF: C34H24N6Na4O14S4 | MW: 960.83, Buy now for reliable and reproducible results from Tristains at Chemical World.
Evans Blue (also known as C.I. 23860 and Direct Blue 53 (CAS No. 314-13-6)) is a synthetic azo dye, designed with the formula C34H24N6Na4O14S4. It is provided in form of dark blue to black crystalline solid and is highly soluble in water and polar solvents. Evans Blue is well known due to its intense blue color and is a good tracer of high molecular weight proteins because it binds to serum albumin. This is a desirable property of it in physiological work, especially in measuring plasma volume and vascular permeability. The fact that it combines reliability with other characteristics makes it a favorite in biomedical, analytical and industry applications.
Applications
- Staining in Cell Biology and Histology: Evans Blue is widely applied in histology and cell staining to emphasize both tissue architecture and cellular constituents to be examined under a microscope.
- Biomedical Research: The dye is vital in studying circulation, vascular permeability and assessing blood-tissue barrier integrity.
- Protein Binding Studies: Evans Blue is widely used in experiments on protein binding because it strongly interacts with serum albumin.
- Analytical Chemistry: Evans blue is bright and stable in blue color, suitable for various methods of analyzing chemistry that demand color consistency.
Key features
- Good Stability of Color: Offers a blue stain that is long-lasting and intense enough to be used in long-term analysis and staining.
- Wide Applicability: Dissolves in water and polar solvents, allowing wide application in laboratory and industrial processes.
- High Stability: Keeps performance and color integrity in diverse environmental conditions.
General Description
Evans Blue C.I. 23860 (CAS No. 314-13-6) is a superior synthetic diazo dye that finds wide application in scientific studies and industrial procedures. It is a high-molecular-weight protein tracer that is vital in the research concerning the vascular permeability and protein binding. With a molecular weight of 960.83 and a deep blue appearance, Evans Blue is usually used in histology, cytology, microbiology, hematology and biomedical research studies.
The dye is bright blue-black with a powder that can be quickly dissolved in water and polar solvents and times it can be easily incorporated into laboratory protocols. Chemical World provides Evans blue C.I. 23860 as a research, diagnostic, and industrial laboratory reagent, which is consistent with and assured quality performance. The purchase and detailed information of the products can be found online. To find the latest prices, large order quantities and favorable prices in Evans Blue C.I. 23860 (CAS No. 314-13-6), please call Chemical World to get reliable laboratory chemical supplies.
About Brand
TriStains provides a marketplace for histology and biological stains, which is comprehensive enough to encompass the peculiar requirements of laboratories specializing in Histology, Cytology, Microbiology, and Hematology. With a reputation for exceeding quality expectations, TriStains performance is outstanding, which allows for the resolution of cell and tissue components fundamental to life sciences to be clearly visualized. Each product under the TriStains series is validated for accuracy, reliability, and consistency. TriStains, which manufactures and markets stains and indicators in various packaging, offers laboratories turnkey solutions for all their staining and indicator needs, improving accuracy in every experiment.
Chemical World provides the best laboratory brands that provide a constant and reliable result for any kind of experiment. Our range of high-quality laboratory brands is complete and is available in various scientific fields. ChemieR supplies high-purity chemicals to be used in reliable laboratories, cUSP supplies certified and standard solutions which can be used right away to assess accurately, and TriStains provides high-quality histological stains and indicators to be used in order to visualize accurately. LiChrom is the provider of liquid chromatography using high-grade reagents, and Bluster is the provider of high-grade solvents used in gas chromatography. EKS focuses on electronics-grade reagents that are used in advanced and sensitive analysis. These brands assure the research, analytical, and industrial laboratories with trusted quality, consistency, and performance. To get your product details, specifications, or to seek any purchasing assistance, visit our site chemicalworlds.com or email our sales team sales@chemicalworlds.com. We are happy to service your laboratory requirements with professional and fast service.
| Alternate Names | Direct blue 53; CI 23860 |
| Application | Evans Blue is an inhibitor of EAAT-mediated L-glutamate uptake |
| CAS Number | 314-13-6 |
| Molecular Weight | 960.83 |
| Molecular Formula: | C34H24N6Na4O14S4 |
Evans blue is a potent inhibitor of L-glutamate uptake into synaptic vesicles via EAAT. Evans Blue also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). The compound is also a P2X-selective purinoceptor antagonist. Used as a dye, Evans blue reduces unwanted fluorescence due to the conjugation and auto fluorescence of structural elements in the tissue or cells.
| Appearance | Powder |
| Physical State | Solid |
| Solubility | Soluble in water. |
| Ki Data | Vesicular glutamate transporter 3: Ki= 40 nM (rat); Autotaxin: Ki= 824 nM (human) |
| Storage | Store at room temperature |
| pK Values | n20D ~1.84 (Predicted) |
| IC50 : | Autotaxin: IC50 = 922 nM (human); Protein-tyrosine phosphatase 1: IC50 = 1200 nM (Saccharomyces cerevisiae); Protein-tyrosine phosphatase 1 B: IC50 = 1300 nM (human) |
SAFETY INFORMATION
| WGK Germany | 3 |
| RTECS | QJ6440000 |
| PubChem CID | 9566057 |
| Merck Index | 14: 3905 |
| MDL Number | MFCD00004021 |
| EC Number | 206-242-5 |
| Beilstein Registry : | 162259 |
| SMILES : | CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N/N=C3/C(=O)C4=C(C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])C=C3)C)N/N=C5/C(=O)C6=C(C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])C=C5.[Na+].[Na+].[Na+].[Na+] |
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